Product Description | This is the most characterized fragment of the HIV transactivator protein (TAT) YGRKKRRQRRR. This arginine-rich TAT peptide penetrates plasma membrane directly, but not through endocytosis. Oligomers of the TAT(47-57) peptide compact plasmid DNA to nanometric particles and stabilize DNA towards nuclease degradation. At optimized vector compositions. these peptides mediated gene delivery to cells in culture 6-8-fold more efficiently than poly-L-arginine or the mutant TAT2-M1 |
