Peptide Nucleotide Acid (PNA)

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Peptide Nucleic Acids (PNAs) are synthetic DNA, or RNA mimics that consist of nucleobases attached to a polyamide backbone. PNAs can bind to both DNA and RNA targets in a sequence-specific manner to form PNA/DNA and PNA/RNA duplex structures. The ability of PNAs to sequence-specifically recognize duplex DNA has attracted considerable interest because of their unparalleled ability to invade double-stranded DNA. Besides, PNA confers remarkable resistance to DNases and proteinases. PNA provides a powerful tool to study the mechanism of transcription and an innovative strategy to regulate target gene expression, antisense, antigene agents, molecular probes, 8-17 DNAzyme, 10-23 DNAzyme and biosensors.

LifeTein provides custom PNA oligos, unlabeled or labeled by fluorescent dyes or other modifications. The PNA oligos can be conjugated to peptides for additional functionality. PNA oligomers can be labeled at 5' and/or 3' end. These labels are available upon request: fluorophores including FAM, FITC, Alexa Fluor dyes, Atto dyes, Cyanine dyes (cy3, cy5, cy7), QSY9, Dylight, quenchers (BHQ, Dabcyl), Acridine, Alkyne (DBCO or Pentynoic acid), Azide, Biotin, Maleimide, Myristol, Palmitic acid, et al. Contact us if your modification is not on the list.

Peptide PNA quencher

PNA Applications

  • Microarrays and biosensors: PNA microarray combined with PCR could detect genetically modified organisms.
  • PCR clamping and artificial restriction enzyme: PNA clamp complementary to wild type sequence hybridizes specifically with wild type and blocks its amplification while allowing amplification of the mutant sequence of the imperfect match.
  • Imaging probes and FISH: The fluorescent dye-conjugated PNA can bind to DNA or RNA quickly, even under low salt.
  • Antisense and antigene drugs: PNA can bind to a complementary sequence of mRNA and change its function. PNA can break up DNA duplexes and form PNA/DNA triplex or double duplexes without denaturing the DNA duplex.
  • miRNA inhibitors: PNA binds complementary RNA more strongly than DNA or RNA does. PNA miRNA inhibitors can be conjugated to cell-penetrating peptides without the need for transfection reagents for cell entry.
  • Double strand DNA invasion and capture: Because of its uncharged polyamide backbone, PNA can hybridize to negatively charged DNA or RNA without electrostatic repulsion.

The PNA length of 10~30 mer is used for most applications because Tm of PNA is higher than that of DNA. A longer PNA with a high purine content (>60%) can reduce water solubility. However, we can add additional lysines, O linker AEEA, E linker, or X linker to increase the water solubility. Please avoid the self-complementary sequences such as inverse repeats, hairpin forming, and palindromic sequences because PNA/PNA interaction is stronger than PNA/DNA interaction.

Featured PNA Products

PMP01-25Peptide nucleotide acid (PNA) PMP01-25: {GGCAAGTCTTCTTCGGA}-NH2  $499     $299, 125nmol,   In Stock
APP01-25Peptide nucleotide acid (PNA) APP01-25: {GGCTCAACTCTGGACAG}-NH2  $499     $299, 125nmol,   In Stock
EcoPNA1169 Peptide nucleotide acid (PNA) EcoPNA1169: Biotin - {CAACACACAGTGTC}  $499     $299, 125nmol,   In Stock
LT8195 (KFF)3K-PNA:KFFKFFKFFK-CTCATACTCT$1200, 125nmol,   In Stock
PNA Monomer AFmoc-PNA-A(Bhoc)-OH  $250     $149,  In Stock
PNA Monomer TFmoc-PNA-T-OH   $250     $149,  In Stock
PNA Monomer G Fmoc-PNA-G(Bhoc)-OH   $250     $149,  In Stock
PNA Monomer C Fmoc-PNA-C(Bhoc)-OH  $250     $149,  In Stock


  • PNA has an electrically neutral backbone. This key feature of high specificity enables rapid hybridization with just a small amount of PNA probes without a significant background signal. So, PNA is very efficient and useful in applying to FISH (fluorescent in situ hybridization) at low concentrations.
  • C-rich probe (repeats of CCCTAA): TelC is a C-rich telomere probe for a leading strand (repeats of TAACCC). It is used to detect human, mouse, and rat chromosomes.
  • G-rich probe (repeats of TTAGGG): TelG is a G-rich telomere probe for lagging strands (repeats of TTAGGG).
  • Pan-centromere probe: Cent probe is specific for human alpha satellite centromere and does not react to the mouse. The sequence of the probe is AAACTAGACAGAAGCAT.
  • CENPB probe: CENPB probe is a binding site for centromere protein B (CENP-B). The probe sequence is ATTCGTTGGAAACGGGA.
  • CAG repeat probes: (CAG)5-Cy3 and (CAG)5-Cy5
  • PNA primer for the cre-lox recombination system: TATAGCATACATTATACGAAGTTAT
  • EcoPNA1169: Biotin - CAACACACAGTGTC. This Nucleic Acid Mimics (NAMs) sequence 5'-CAA CAC ACA GTG TC-3' hybridizes between positions 1169 and 1183 of E. coli O157:H7 strain TW14359 (CP_001368).

PNA Inhibitors

  • PNA specifically binds to the miRNAs that are paired with each other and inhibits the regulation of miRNA itself.
  • Mitochondria rRNA blocker: GGCAAGTGTTCTTCGGA
  • Chloroplast rRNA blocker: GGCTCAACCCTGGACAG
  • Internal Transcribed Spacers (ITS) rRNA blocker: CGAGGGCACGTCTGCCTGG
  • 8-17 DNAzyme, 10-23 DNAzyme

Probe Ex (nm) Em (nm) MW Notes
Alexa 488 dye 490 525 699.7
FITC or FAM 495 519 389 pH sensitive
Cyanine Cy2 492 510
Cyanine Cy3 550 570
Alexa 555 dye 555 580 534.5
Rhodamine B 570 590
Abberior Star635 635 655 911 STED and Confocal Imaging
Cyanine Cy5 650 670
Silicon-Rhodamine (SiR) 652 674 472.61 Multicolour Live Cell Imaging
Displaying 1 to 8 (of 8 Products)
Price Product Name-
$598.80 $299.00Save: 50% off... more info
Product NameAPP01-25Product Quantity 125nmolCatalog Number LT-PNA002 Purity >95% Sequence {GGCTCAACTCTGGACAG}-NH2 Description PNA probes have no direct interaction with DNA polymerase. However, PNAs can terminate the elongation of...
$598.80 $299.00Save: 50% off... more info
Product NameEcoPNA1169Product Quantity 125nmolCatalog Number LT-PNA003 Purity >95% Sequence Biotin - {CAACACACAGTGTC} Description This Nucleic Acid Mimics (NAMs) sequence 5'-CAA CAC ACA GTG TC-3' hybridizes between positions 1169 and 1183 of E....
$250.00 $149.00Save: 40% off... more info
Product NameFmoc-C(Bhoc)-Aeg-OHProduct Quantity 1 GramCatalog Number LT-PNA007 Purity >95% CAS Number 186046-81-1 Molecular Formula C39H35N5O8 Molecular Weight 701.72 Description Description: Fmoc-PNA-C(Bhoc)-OH is designed for the synthesis...
$250.00 $149.00Save: 40% off... more info
Product NameFmoc-G(Bhoc)-Aeg-OHProduct Quantity 1 GramCatalog Number LT-PNA006 Purity >95% CAS Number 186046-83-3 Molecular Formula C40H35N7O8 Molecular Weight 741.75 Description Description: Fmoc-PNA-G(Bhoc)-OH, representing the Guanine (G)...
$250.00 $149.00Save: 40% off... more info
Product NameFmoc-A(Bhoc)-Aeg-OHProduct Quantity 1 GramCatalog Number LT-PNA004 Purity >95% CAS Number 186046-82-2 Molecular Formula C40H35N7O7 Molecular Weight 725.75 Description Description: Fmoc-PNA-A(Bhoc)-OH is a specialized monomer for...
$250.00 $149.00Save: 40% off... more info
Product NameFmoc-T-Aeg-OH; Fmoc-PNA-T-OHProduct Quantity 1 GramCatalog Number LT-PNA005 Purity >95% CAS Number 169396-92-3 Molecular Formula C26H26N4O7 Molecular Weight 506.51 Description Description: Fmoc-PNA-T-OH is a specialized monomer...
$1,200.00... more info
Product Name (KFF)3K-PNA:KFFKFFKFFK-CTCATACTCTProduct Quantity 125nmolCatalog Number LT8195 Purity >95% Sequence KFFKFFKFFK-{CTCATACTCT}-NH2 Description The acpP-targeting antisense PNA CTCATACTCT, particularly when linked to the cell...
$598.80 $299.00Save: 50% off... more info
Product NamePMP01-25Product Quantity 125nmolCatalog Number LT-PNA001 Purity >95% Sequence {GGCAAGTCTTCTTCGGA}-NH2 Description PNA probes have no direct interaction with DNA polymerase. However, PNAs can terminate the elongation of...
Displaying 1 to 8 (of 8 Products)
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