Cosmetic Peptides

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It is highly challenging to deliver cosmetic actives and drugs to the skin because of the stratum corneum (SC). The permeability of large hydrophilic peptides or compounds across the stratum corneum on the outer skin surface is extremely low because of the lipophilic properties of the uppermost skin layer.

A short synthetic peptide was found to facilitate efficient transdermal protein drug delivery through the intact skin. Besides, the transdermal-enhancing activity of the peptide was sequence-specific and dose-dependent. The peptide creates a temporary opening in the skin barrier to enable insulin or other drugs to reach systemic circulation. So peptides hold potential as drug delivery vehicles for cosmetic purposes because of their simplicity, biocompatibility, and multi-functionality.

The delivery system was applied to treat melisma. Treatment with a cream formulation containing the transdermal peptide co-administered with other agents resulted in measurable inhibition of melanin production and melanocyte apoptosis. After four weeks of application, patients demonstrated a significant lightening of facial hypomelanosis lesions and almost wholly restored dark lesions to normal skin color after 12 weeks. These innovative peptide technologies give patients even, young, and healthy-looking skin. Its topical application induces restoration of the skin’s most important structural dermal components.

LifeTein is working on a safe cell penetration peptide for the co-administration with another short cosmetic peptide. A few short peptide candidates have been proven to significantly and visibly improve the skin’s evenness and overall appearance, and reduce keratinocyte-induced activation of melanocytes. Together with the cell penetration peptides, the cosmetic peptide acts safely and as a result inhibits the skin pigmentation process, which is of major cosmetic concern.

Cosmetic Peptides

Transdermal Peptide TD1 ACSSSPSKHCG, acetylated, amidated
Tetrapeptide PKEKPro-Lys-Glu-Lys (PKEK), acetate salt
Bioactive tetrapeptide GEKGBioactive tetrapeptide GEKG, acetate salt
Tripeptide-1GHK; Gly-His-Lys
Tripeptide-1(Copper Peptide)(GHK)2-Cu; (Gly-His-Lys)2Cu
Palmitoyl Tripeptide-1Pal-Gly-His-Lys
Argireline; Acetyl Hexapeptide-3 Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2
Eyeseryl; AcetyltetrapeptideAc-Beta-Ala-His-Ser-His-OH
Matrixyl; Palmitoyl PentapeptidePAL-Lys-Thr-Thr-Lys-Ser-OH
Melanostatin DMHis-D-Arg-Ala-Trp-D-Phe-Lys-NH2
Pal-AHK Pal-Ala-His-Lys
Rigin(Pal-GQPR); Palmitoyl Tetrapeptide -3Pal-Gly-Gln-Pro-Arg-OH
Snap-8; Acetyl Octapeptide-8Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
Syn-Coll; Palmitoyl Tripeptide-5Pal-Lys-Val-Lys-OH
Vialox; Pentapeptide-3VH-Gly-Pro-Arg-Pro-Ala-NH2
Displaying 1 to 10 (of 12 Products)
Price Product Name-
$120.00... more info
Argireline Acetate
Catalog Number: 54947 Category: Argireline, Acetyl hexapeptide-3 or acetyl hexapeptide-8 Sequence: Ac-EEMQRR-NH2 ; Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2 Function: Acetyl hexapeptide-3 is used in attempts to decrease the visible effects of aging by...
$300.00 $150.00Save: 50% off... more info
Bioactive tetrapeptide GEKG
Product Name Bioactive tetrapeptide GEKG, acetate salt Product Description Bioactive tetrapeptide GEKG boosts extracellular matrix formation. The topical application of the matrikine GEKG to human skin stimulates ECM protein expression of collagen...
$239.40... more info
Catalog Number: 6303-Cu Category: Pal-GHK-Copper, CAS Number:300801-03-0 Sequence: (GHK)2-Cu, (Gly-His-Lys)2Cu; Gly-His-Lys-Cu(II) Modifications: GHK-Cu is a complex of the tripeptide Gly-His-Lys and a copper(II) ion that has wound healing and...
$250.00... more info
Catalog Number: LT8196 Name: Nonapeptide-1 Peptide Sequence:H-Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 Description: Nonapeptide-1, identified by the CAS number 158563-45-2 and the sequence Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2, is a...
$280.00... more info
Catalog Number: 6303 Category: Tripeptide-1, GHK, CAS Number:147732-56-7 Sequence: Pal-GHK, Pal-Gly-His-Lys; C16-GHK; C16-GK-3 ; Palmitoyl Oligopeptide; Palmitoyl Tripeptide-1 Modifications: Pal-GHK is a form of the extracellular...
$280.00... more info
Catalog Number: 6299 Category: Peptide Sequence: Pal-KTTKS Modifications: Quantity: 10mg Purity: 98 % Notes:
$280.00... more info
Catalog Number: 6331 Category: Peptide Sequence:Palmitoyl Tripeptide-5; Palm-Lys-Val-Lys Modifications: Palmitoyl tripeptide-5 is a cosmeceutical peptide. Quantity: 5mg, gram or kilogram scale peptides available upon request Purity: 98 %...
$120.00... more info
Palmitoyl pentapeptide-4
Catalog Number: 53886 Category: Matrixyl, Palmitoyl Pentapeptide Sequence: Pal-Lys-Thr-Thr-Lys-Ser-OH, Pal-KTTKS Function: Palmitoyl pentapeptide-4 (Pal-Lys-Thr-Thr-Lys-Ser-OH; Pal-KTTKS) contains 5 amino acids linked to a 16-carbon aliphatic...
$280.00... more info
Palmitoyl Tetrapeptide-7 Rigin Pal-GQPR
Catalog Number: 6300 Category: Peptide Sequence:Rigin, Palmitoyl Tetrapeptide -3: Pal-GQPR, Pal-Gly-Gln-Pro-Arg-OH Modifications: Palmitoyl Tetrapeptide-7 (also known as Rigin™) is a lipopeptide from Sederma designed to mimic DHEA activity...
$300.00 $150.00Save: 50% off... more info
Tetrapeptide PKEK
Product Name Bioactive tetrapeptide Pro-Lys-Glu-Lys (PKEK), acetate salt Product Description Bioactive tetrapeptide PKEK, has proven skin-lightening benefits on skin discoloration from melasma and postinflammatory hyperpigmentation. The...
Displaying 1 to 10 (of 12 Products)
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