Cosmetic Peptides

It is highly challenging to deliver cosmetic actives and drugs to the skin because of the stratum corneum (SC). The permeability of large hydrophilic peptides or compounds across the stratum corneum on the outer skin surface is extremely low because of the lipophilic properties of the uppermost skin layer.

A short synthetic peptide was found to facilitate efficient transdermal protein drug delivery through the intact skin. Besides, the transdermal-enhancing activity of the peptide was sequence-specific and dose-dependent. The peptide creates a temporary opening in the skin barrier to enable insulin or other drugs to reach the systemic circulation. So peptides hold potential as drug delivery vehicles for cosmetic purposes because of their simplicity, biocompatibility, and multi-functionality.

The delivery system was applied to treat melisma. Treatment with a cream formulation containing the transdermal peptide co-administered with other agents resulted in measurable inhibition of melanin production and melanocyte apoptosis. After four weeks of application, patients demonstrated a significant lightening of facial hypermelanosis lesions and almost wholly restored dark lesions to normal skin color after 12 weeks. These innovative peptide technologies give the patients even, young, and healthy-looking skin. Its topical application induces restoration of the skin’s most important structural dermal components.

LifeTein is working on a safe cell penetration peptide for the co-administration with another short cosmetic peptide. A few short peptide candidates have been proved to significantly and visibly improve the skin’s evenness and overall appearance, and reduce keratinocyte-induced activation of melanocytes. Together with the cell penetration peptides, the cosmetic peptide acts safely and as a result inhibits the skin pigmentation process, which is of major cosmetic concern.

Cosmetic Peptides

                                                                                                                                                                                                                                                                                                                                                                                                                           
Tripeptide-1GHK; Gly-His-Lys
Tripeptide-1(Copper Peptide)(GHK)2-Cu; (Gly-His-Lys)2Cu
Palmitoyl Tripeptide-1Pal-Gly-His-Lys
Argireline; Acetyl Hexapeptide-3 Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2
Decapeptide-12H-Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr-OH
Eyeseryl; AcetyltetrapeptideAc-Beta-Ala-His-Ser-His-OH
LeuphasylH-Tyr-D-Ala-Gly-Phe-Leu-OH
LipopeptidePAL-Val-Gly-Val-Ala-Pro-Gly-OH
Matrixyl; Palmitoyl PentapeptidePAL-Lys-Thr-Thr-Lys-Ser-OH
Melanostatin DMHis-D-Arg-Ala-Trp-D-Phe-Lys-NH2
Nonapeptide-1H-Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2
AHKAla-His-Lys
AHK-Cu(Ala-His-Lys)2Cu
Pal-AHK Pal-Ala-His-Lys
Pal-Lys-Val-Dab-OHPal-Lys-Val-Dab-OH
Pal-Lys-Val-Dab-Thr-OHPal-Lys-Val-Dab-Thr-OH
Rigin(Pal-GQPR); Palmitoyl Tetrapeptide -3Pal-Gly-Gln-Pro-Arg-OH
Snap-8; Acetyl Octapeptide-8Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
Syn-AKEH-beta-Ala-Pro-Dab-NH-Bzl
Syn-Coll; Palmitoyl Tripeptide-5Pal-Lys-Val-Lys-OH
Vialox; Pentapeptide-3VH-Gly-Pro-Arg-Pro-Ala-NH2
               
$100.00
... more info

Argireline Acetate

Catalog Number: 54947 Category: Argireline, Acetyl hexapeptide-3 or acetyl hexapeptide-8 Sequence: Ac-EEMQRR-NH2 ;...
$250.00  $150.00
Save: 40% off
... more info

Bioactive tetrapeptide GEKG

Product Name Bioactive tetrapeptide GEKG, acetate salt Product Description Bioactive tetrapeptide GEKG boosts extracellular matrix formation. The...
$199.50
... more info

GHK-Copper

Catalog Number: 6303-Cu Category: Pal-GHK-Copper, CAS Number:300801-03-0 Sequence: (GHK)2-Cu, (Gly-His-Lys)2Cu; Gly-His-Lys-Cu(II)...
$199.50
... more info

Pal-GHK

Catalog Number: 6303 Category: Tripeptide-1, GHK, CAS Number:147732-56-7 Sequence: Pal-GHK, Pal-Gly-His-Lys; C16-GHK; C16-GK-3 ; Palmitoyl...
$201.60
... more info

Pal-KTTKS

Catalog Number: 6299 Category: Peptide Sequence: Pal-KTTKS Modifications: Quantity: 10mg Purity: 98 % Notes:
$199.50
... more info

Palm-Lys-Val-Lys

Catalog Number: 6331 Category: Peptide Sequence:Palmitoyl Tripeptide-5; Palm-Lys-Val-Lys Modifications: Palmitoyl tripeptide-5 is a...
$100.00
... more info

Palmitoyl pentapeptide-4

Catalog Number: 53886 Category: Matrixyl, Palmitoyl Pentapeptide Sequence: Pal-Lys-Thr-Thr-Lys-Ser-OH, Pal-KTTKS Function: Palmitoyl...
$199.50
... more info

Palmitoyl Tetrapeptide-7 Rigin Pal-GQPR

Catalog Number: 6300 Category: Peptide Sequence:Rigin, Palmitoyl Tetrapeptide -3: Pal-GQPR, Pal-Gly-Gln-Pro-Arg-OH Modifications: Palmitoyl...
$250.00  $150.00
Save: 40% off
... more info

Tetrapeptide PKEK

Product Name Bioactive tetrapeptide Pro-Lys-Glu-Lys (PKEK), acetate salt Product Description Bioactive tetrapeptide PKEK, has proven skin-lightening...
$136.50
... more info

Tripeptide-1-GHK

Catalog Number: 6350 Category: Tripeptide-1, CAS Number: 49557-75-7 Sequence: GHK; Gly-His-Lys Modifications: GHK is a peptide released during...
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