Proteins

We provide cytokines, growth factors, chemokines, CD antigens, neurotrophins, hormones, enzymes, viral antigens, recombinant proteins, natural proteins, monoclonal antibodies, and polyclonal antibodies.

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Featured Proteins of Coronavirus Disease 2019 (COVID-19): SARS-CoV-2 Spike RBD Protein, Nucleocapsid Protein, ACE2 Protein

   

2019 Novel Coronavirus SARS-CoV-2 is a virus identified as the cause of an outbreak of respiratory illness Covid-19 first detected in Wuhan, China. The coronavirus Nucleocapsid (N) of Coronavirus forms the helical ribonucleocapsid complexes with positive-strand viral genomic RNA. It plays an important role in virus replication, transcription, and assembly.

The coronavirus Spike protein (S) is a large oligomeric transmembrane protein that mediates coronavirus entry into host cells. It contains S1 and S2 two subunits. The receptor-binding domain (RBD) of the S1 subunit recognizes host cell surface receptors. S2 subunit is responsible for membrane fusion.

The Covid-19 uses the cellular Angiotensin converting enzyme 2 (ACE2) protein as a receptor for cellular entry.

Peptides for COVID-19 Research

                                                                                                                                                                                                                                                   

LT5578	2019 Coronavirus SARS-CoV-2 Receptor Binding Motif	$990     $499,  In Stock
LT5587	Coronavirus SARS-CoV-2 Surface Glycoprotein, 74 amino acids	$1000     $100,  In Stock
LT5588	South Africa Mutant B.1.1.529: Coronavirus SARS-CoV-2 Surface Glycoprotein, 74 amino acids	$1000
LT-V007	SBP1: Peptide binder to the SARS-CoV-2 spike protein	$450, In Stock
LT-V008	Biotin-SBP1: Biotin-Peptide binder to the SARS-CoV-2 spike protein	$450, In Stock
LT-V012	SARS-CoV-2 Receptor Binding Domain Overlapping Peptide Library, 22 Peptides, 15mer, 5 amino acid overlapping	$1980     $1386,  In Stock
LT-V013	SARS-CoV-2 Receptor Binding Domain Peptide Library, 4 Peptides, 20mer without overlapping	$499,  In Stock
LT-V014	Angiotensin-converting enzyme 2 (ACE2) substrates and peptides	Call for Quote,  2-3 weeks
LT-V015	Aviptadil (Senatek), Vasoactive intestinal polypeptide	Call for Quote,  2-3 weeks

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Order PepMag Magnetic Agarose beads for easy peptide conjugation, pull down experiment and binding assays. Simply mix the agarose beads with your peptide through reactions with the amine groups on the peptide. The high surface area of porous magnetic agarose beads results in high binding capacities. The binding of peptide and agarose beads are permanent. For binding with your target protein or antibody, simply mix the conjugated beads with your samples, Wash the beads, and elute the protein or antibody using 50 mM glycine pH 2.5. Any buffer that breaks the binding between peptide/protein or peptide/antibody can be used for elution.

Highlights

                                                                                                                                                                                                                                                                                                     

LTP4418	Recombinant Mouse RANKL Protein	$1000 $500
LT13501	Macrophage Colony Stimulating Factor (M-CSF)	$650 $300
LTCY-0001	Mannose-6-phosphate isomerase	$1500 $950
LTCN12115	Human Sphingomyelin synthase 1, recombinant	$9,000
LTCN12116	Human Sphingomyelin synthase 2, recombinant	$9,000
LT16323	Thiol-Activated Peptide Conjugation Magnetic Beads	$320
LT13513	Amine-activated Peptide Conjugation Magnetic Beads	$320
LT12010	Recombinant Human Copper, Zinc-Superoxide Dismutase	$230

LifeTein provides special protein products including Alkali-tolerant Protein A, Protein G, streptavidin, human fibroblast growth factors, human vascular endothelial growth factor, human growth hormone, and human copper, zinc-superoxide dismutase.

Protein A is derived from Staphylococcus aureus. Protein G is derived from a Streptococcus species. Both have binding sites for the Fc portion of mammalian IgG. Protein G has a higher affinity for rat, goat, sheep, and bovine IgG, as well as for mouse IgG1 and human IgG3. Protein A has a higher affinity for cat and guinea pig IgG. Protein G is recommended for most species, including mice and rats. Protein A is recommended for cats and guinea pigs. Neither is recommended for the detection of IgA or IgM, for the detection of Fab fragments, or for the detection of avian IgG.

Streptavidin is a tetrameric protein that binds very tightly to the small molecule, biotin. The binding constant for this interaction is very high and has made the streptavidin/biotin system the tool for intermolecular interactions.

Fibroblast Growth Factor-basic (FGF-b) is a heparin-binding growth factor that stimulates the proliferation of a wide variety of cells including mesenchymal, neuroectodermal, and endothelial cells.

LifeTein's recombinant Superoxide Dismutase belongs to Human Copper, Zinc-Superoxide Dismutase (rh-SOD1). Superoxide dismutase is a metalloenzyme. This enzyme binds to molecules of copper and zinc to break down toxic, charged oxygen molecules called superoxide radicals.

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Protein Products:

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       

Cat. No	Product Name	Price	Download          Data Sheet	Order
LT12008	Recombinant Staphylococcal Protein A	$238 $158
LT12014	Alkali-tolerant recombinant Protein A Agarose Resin	$280 $150
LT12007	Recombinant Streptococcus Protein G	$280 $198
LT12015	Recombinant Protein G Agarose Resin	$350 $165
LT13512	Protein A Magnetic Agarose Resin	$280
LT13513	Peptide Conjugation Magnetic Agarose Resin	$280
LT12009	Recombinant Streptavidin (r-SA)	$330 $158
LT12012	Recombinant Human Fibroblast Growth Factor-Basic	$380 $290
LT12012-02	Recombinant Human Fibroblast Growth Factor Basic Agarose	$500 $350
LT12011	Recombinant Human Vascular Endothelial Growth Factor	$370
LT12011-02	Recombinant Human Vascular Endothelial Growth Factor Agarose	$500 $350
LT12013	Recombinant Human Growth Hormone	$220
LT12010	Recombinant Human Copper, Zinc-Superoxide Dismutase	$230

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Affinity of Protein A/G for IgG Types from Different Species

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             

Species	Immunoglobulin	Binding to Protein A	Binding to Protein G
Human	lgG (normal)	++++	++++
	lgG1	++++	++++
	lgG2	++++	++++
	lgG3	-	++++
	lgG4	++++	++++
	lgM	-	-
	lgA	-	-
	lgE	-	-
Mouse	lgG1	+	++++
	lgG2a	++++	++++
	lgG2b	+++	+++
	lgG3	++	+++
Rat	lgG1	-	+
	lgG2a	-	++++
	lgG2b	-	++
	lgG2c	+	++
Goat	lgG	+/-	++
Rabbit	lgG	++++	+++
Sheep	lgG	+/-	++