Recombinant Human Copper, Zinc-Superoxide Dismutase (rh-SOD1)

Alternative Name:
Superoxide Dismutase1 (SOD1)
Catalog Number:
LT12010
Packing Details:
10mg
Physical Appearance:
Freeze-dried powder
Mol. Wt.:
17 kDa
N-terminus Sequenced:
ATKAVCVLKG; Full sequence: MATKAVCVLK GDGPVQGIIN FEQKESNGPV KVWGSIKGLT EGLHGFHVHE FGDNTAGCTS AGPHFNPLSR KHGGPKDEER HVGDLGNVTA DKDGVADVSI EDSVISLSGD HCIIGRTLVV HEKADDLGKG GNEESTKTGN AGSRLACGVI GIAQ
Resources:
Escherichia coli
Purity:
≥ 95%
Endotoxins:
< 1.0 EU/µg protein
Metals:
Cadmium < 0.5 ppm; Mercury < 0.5 ppm; Lead < 6.5 ppm (1 ppm=1 µg metal/g protein)
Specific Activity:
≥ 10,000 IU/mg protein (Determined by Marklund assay at 35°C)
≥ 10,380 IU/mg protein (Determined by SGS according to GB/T5009.171-2003 I)
Storage:
-20°C in the dark
Shelf Life:
3 years
Description:

Superoxide dismutase is a metalloenzyme. It is present in all living organisms, including animals, plants, and microorganisms. SOD is categorized based on its metallicity into copper, zinc-SOD (Cu, Zn-SOD), manganese-SOD (Mn-SOD), and iron-SOD (Fe-SOD). LifeTein's recombinant Superoxide Dismutase belongs to Human Copper, Zinc-Superoxide Dismutase (rh-SOD1). LifeTein's Superoxide Dismutase1 (SOD1) is expressed and purified from E.coli. The N terminal sequence is ATKAVCVLKG. This enzyme binds to molecules of copper and zinc to break down toxic, charged oxygen molecules called superoxide radicals. The physiological significance of SOD is that it can convert toxic superoxide free radicals into hydrogen peroxide.

Studies have shown that SOD can play a critical role in reducing internal inflammation and lessening pain associated with conditions such as arthritis. Supplement with oral preparations of pure SOD enzyme is not effective because the SOD protein is easily deactivated by acids and enzymes contained in the digestive tract.  However scientists have created bioavailable forms of SOD using natural plant extracts. When delicate SOD molecules are coupled with a protective protein derived from wheat and other plants, they can be delivered intact to the intestines and absorbed into the bloodstream, thus effectively enhancing the body™s own primary defense system.

SOD is a key component in cosmetic products and has been approved by many countries because it can delay aging, regulate immune response, and blood lipid levels, and prevent damage from solar radiation. SOD is an unusually stable enzyme although its apoenzyme is very unstable. 

Images:
Recombinant Human Copper, Zinc-Superoxide Dismutase (rh-SOD1)Superoxide-Dismutase

Notes:
It is recommended that the product be reconstituted with sterile water into a final concentration of 10 mg/ml . Avoid multiple freeze-thaw cycles and exposure to frequent changes in temperature.

The use of strong acids and bases, strong oxidants, and high concentrations of organic solvents should be avoided to prevent denaturation.
For research use only!
  • 49 Units in Stock

$230.00

Qty Discounts New Price
1-9
$230.00
10-49
$120.00
50+
$45.00
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