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The Nobel Prize in Chemistry 2022 awarded to Carolyn R. Bertozzi, Morten Meldal, and K. Barry Sharpless for their outstanding work with click chemistry, a well-deserved honor for developing a vital and straightforward technique in modern chemistry. Barry Sharpless, with this as his second Nobel Prize in Chemistry, and Morten Meldal independently presented the idea of click chemistry over twenty years ago. The reactions involved are highly versatile and can be performed under a multitude of conditions, making the method incredibly efficient and applicable to many fields. In a perfect example, Carolyn Bertozzi, who was jointly awarded this Nobel Prize, utilized the principles of click chemistry to present bioorthogonal chemistry, click reactions that take place within living organisms without disrupting the normal chemistry of the cell. Since its inception, click chemistry has had its influence explored across many other facets of chemistry, including very useful applications in peptide synthesis.
LifeTein frequently uses Cu(I)-catalyzed Azide-Alkyne Click Chemistry reaction (CuAAC), Strain-promoted Azide-Alkyne Click Chemistry reaction (SPAAC), or Ligation between tetrazine and alkene (trans-Cyclooctene) reaction in its peptide-drug conjugation service. Such reactions would not be nearly as feasible without the simple answer of click chemistry, as linking large and functionalized molecules like peptides and oligonucleotides is a very challenging task otherwise. With this, LifeTein is able to provide peptide-drug, DNA-peptide conjugates and RNA-peptide conjugates for cell screening and in vivo studies with ease.
LifeTein Conjugation Services
Reference: doi: 10.1007/s11095-015-1657-7
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