Please click here to get a quote for Peptide Nucleic Acids service now!
Peptide Nucleic Acids (PNAs) are synthetic DNA, or RNA mimics that consist of nucleobases attached to a polyamide backbone. PNAs can bind to both DNA and RNA targets in a sequence-specific manner to form PNA/DNA and PNA/RNA duplex structures. The ability of PNAs to sequence-specifically recognize duplex DNA has attracted considerable interest because of their unparalleled ability to invade double-stranded DNA. Besides, PNA confers remarkable resistance to DNAses and proteinases. PNA provides a powerful tool to study the mechanism of transcription and an innovative strategy to regulate target gene expression, antisense, antigene agents, molecular probes, and biosensors.
LifeTein provides custom PNA oligos, unlabeled or labeled by fluorescent dyes or other modifications. The PNA oligos can be conjugated to peptides for additional functionality. PNA oligomers can be labeled at 5' and/or 3' end. These labels are avaialble upon request: fluorophores including FAM, FITC, Alexa Fluor dyes, Atto dyes, Cyanine dyes (cy3, cy5, cy7), QSY9, Dylight, quenchers (BHQ, Dabcyl), Acridine, Alkyne (DBCO or Pentynoic acid), Azide, Biotin, Maleimide, Myristol, Palmitic acid et al. Contact us if your modification is not on the list.
The PNA length of 10~30 mer is used for most applications because Tm of PNA is higher than that of DNA. A longer PNA with a high purine content (>60%) can reduce the water solubility. However, we can add additonal lysines, O linker AEEA, E linker, or X linker to increase the water solubility. Please avoid the self-complementary sequences such as inverse repeats, hairpin forming, and palindromic sequences because PNA/PNA interaction is stronger than PNA/DNA interaction.