Peptide Nucleic Acids (PNAs)

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LifeTein Peptide Nucleic Acids: Synthetic Oligonucleotides

Peptide synthesis: Peptide Nucleic Acids

Peptide Nucleic Acids (PNAs) are synthetic DNA or RNA mimics that consist of nucleobases attached to a polyamide backbone. PNAs can bind to both DNA and RNA targets in a sequence-specific manner to form PNA/DNA and PNA/RNA duplex structures. The ability of PNAs to sequence-specifically recognize duplex DNA has attracted considerable interest because of their unparalleled ability to invade double-stranded DNA. In addition, PNA confers remarkable resistance to DNAses and proteinases. PNA provides a powerful tool to study the mechanism of transcription and an innovative strategy to regulate target gene expression, antisense and antigene agents, molecular probes and biosensors.

PNA Applications

  • Microarrays and biosensors: PNA microarray combined with PCR could detect genetically modified organisms.
  • PCR clamping and artificial restriction enzyme: PNA clamp complementary to wild type sequence hybridizes specifically with wild type and blocks its amplification while allowing amplification of mutant sequence of imperfect match.
  • Imaging probes and FISH: The fluorescent dye-conjugated PNA can bind to DNA or RNA quickly even under low salt.
  • Antisense and antigene drugs: PNA can bind to complementary sequence of mRNA and change its function. PNA can break up DNA duplex and form PNA/DNA triplex or double duplexes without denaturing the DNA duplex.
  • miRNA inhibitors: PNA binds complementary RNA more strongly than DNA or RNA does. PNA miRNA inhibitors can be conjugated to cell penetrating peptide without the need of transfection reagents for cell entry.
  • Double strand DNA invasion and capture: Because of its uncharged polyamide backbone, PNA can hybridize to negatively charged DNA or RNA without electrostatic repulsion.

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