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Peptide Nucleic Acids (PNAs) 🧬 are synthetic singlestranded DNA, or RNA mimics that consist of nucleobases attached to a polyamide backbone. The DNA-like PNAs' sugar-phosphodiester moiety is replaced with an uncharged N-(2-aminoethyl) glycine and the nucleobases are attached via a methyl carbonyl linker. The PNAs can sequence-specifically recognize duplex DNA and have remarkable resistance to DNases and proteinases. PNA provides a powerful tool in research and clinical applications as antisense agents in developing gene-specific therapeutics for various diseases including cancer as novel antibiotics and antivirals. PNAs have been widely used in molecular diagnostics and therapeutics from regulation target gene expression, gene silencing, antisense, antigene agents, molecular probes, biosensors, to fluorescent in-situ hybridization probes (FISH) and single nucleotide polymorphisms (SNPs) detection.
LifeTein provides custom PNA oligos, unlabeled or labeled by fluorescent dyes or other modifications. The PNA oligos can be conjugated to peptides for additional functionality. PNA oligomers can be labeled at 5' and/or 3' end. These labels are available upon request: fluorophores including FAM, FITC, Alexa Fluor dyes, Atto dyes, Cyanine dyes (cy3, cy5, cy7), QSY9, Pyrene, Dylight, quenchers (BHQ, Dabcyl), Acridine, Butyric acid, Alkyne (DBCO or Pentynoic acid), Azide, Biotin, photocleavable biotin, Maleimide, Myristol, Palmitic acid, et al. Contact us if your modification is not on the list.
|Probe||Ex (nm)||Em (nm)||MW||Notes|
|Alexa 488 dye||490||525||699.7|
|FITC or FAM||495||519||389||pH sensitive|
|Alexa 555 dye||555||580||534.5|
|Abberior Star635||635||655||911||STED and Confocal Imaging|
|Silicon-Rhodamine (SiR)||652||674||472.61||Multicolour Live Cell Imaging|