Oligonucleotide-peptide conjugates are chimeric molecules composed of a nucleic acid moiety covalently linked to a peptide moiety. It is an important tool for studies of the protein– and peptide–nucleic acid interactions, as well as being promising bioconjugates for nucleic acid delivery and therapy.
Conjugation of these large and functionalized molecules is a difficult task. In most cases a direct synthesis of oligonucleotide peptide conjugates is not possible. However, these conjugation problems are solved by LifeTein's PeptideSyn click chemistry on peptides by protecting or modifying functional groups. Our chemoselective ligation method can form very efficient linkage and reaction between the oligonucleotides and peptides.
Synthetic peptides have been shown to be valuable tools for laboratory diagnosis. The peptide-based diagnostic tests is to achieve recognition of specific antibodies induced by whole viral proteins by using selected short fragments containing the most potent antigenic determinants. The oligo-peptide conjugate can be used as DNA-directed immobilization for the binding of multiple antigens to a solid support. Moreover, oligo peptide conjugate has recently been shown to improve the therapeutic potential of oligonucleotides in siRNA, cell permeable peptides and aptamer approaches.
Linear Peptide Oligonucleotide Conjugate
LifeTein offers DNA-peptide conjugate and RNA-peptide conjugate for cell screening and in vivo studies. For RNA peptide conjugate, 2′-O-methyl RNA is a recommended analog, which is resistant to degradation by single-stranded ribonucleases. LifeTein will order oligonucleotide at competitive price directly from IDT. The click chemistry will be used. Both the peptide and oligonucleotide are are modified for the bioorthogonal ligation reactions.
Multiple Antigenetic Peptide Oligonucleotide Conjugate
Cell Permeable Peptide Oligonucleotide Conjugate
Cell-Permeable Peptides (CPPs) or a peptide of choice can be conjugated to an oligonucleotide for drug carrier and delivery.
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