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Click chemistry emerges as a promising avenue for facilitating the seamless linkage of synthetic molecular fragments, thereby enabling the creation of larger and more intricate molecular structures. Among the most prevalent click reactions is the 1,3-dipolar cycloaddition of azides to terminal alkynes, culminating in the formation of 1,2,3-triazoles. LifeTein offers an extensive array of lipids equipped with terminal alkyne, azide moieties or methyltetrazine, providing a diverse selection for initiating your click reactions. A methyltetrazine moiety that participates in an inverse electron-demand Diels–Alder (IEDDA) reaction with strained alkenes (for example, trans-cyclooctene (TCO) or norbornene) in a copper-free “click” fashion. Explore the featured products below to find the components essential for commencing your specific synthesis endeavors!
Discover more about Peptide Drug Conjugation and linkers and spacers.
| 16:0 Azido Coenzyme A |
| 16:0 azidocaproyl PE |
| 16:0 DBCO PE |
| 16:0(alkyne) 18:1 PC |
| 16:0(alkyne) 18:1 PE |
| 18:0 azidoethyl PC |
| 18:0 propargyl PC |
| 18:1 DBCO PE |
| 18:1 Photoclick cholesterol II |
| 18:1 propargyl PC |
| alkyne cholesterol |
| arachidonic acid alkyne |
| Azido sphingosine (d14:1) |
| Clickable Chenodeoxycholic acid |
| Clickable Cholic acid |
| DSPE PEG(2000) Azide |
| DSPE PEG(2000) DBCO |
| Oleic Acid (18 azido) |
| oleic acid(17 yne) |
| pacFA 18:1 PC |
| pacFA Ceramide |
| pacFA GalCer |
| Palmitic acid (15 yne) |
| Photoclick C6 Ceramide |
| PhotoClick Cholesterol |
| Photoclick Sphingosine |
| Trifunctional fatty acid |
| Trifunctional Sphingosine |
| alkyne cholesterol |
| The peptide–tetrazine conjugate is ready to react with a partner bearing a strained alkene (e.g., TCO), performing the IEDDA ligation under mild, bio-compatible conditions. The result is a peptide–linker–second partner conjugate. |
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