2019 Coronavirus SARS-CoV-2 Spike S1 RBD Protein-1mg

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Description:2019 Coronavirus SARS-CoV-2 Spike S1 RBD Protein

Product: Recombinant protein from the receptor-binding domain (RBD) of 2019 Spike S1 of Wuhan pneumonia virus (MN908947.3) SARS-CoV-2, with a human IgG1 Fc tag.

Host: Human cells

RefSeq: MN908947.3; QHD43416.1;

Molecular Weight: 52.3 kDa

Applications: Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies

Background: The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. The SARS-CoV-2 spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S RBD protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV-2 (2019-nCoV) as in recent COVID-19 outbreak.

Quantity: 1 mg, >Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg)

Purity: >90% by SDS-PAGE gel and Coomassie Blue staining

Formulation: Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives

Download Data File:download pdf data sheet

SDS-PAGE & Biological Activity:: Predicted MW of this product is ~ 52 kDa when running on SDS-PAGE under the reduced condition

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