Name: 2019 Coronavirus SARS-CoV-2 Nucleocapsid Protein
Description: Recombinant protein of SARS-CoV-2 nucleocapsid phosphoprotein (N) from Wuhan pneumonia virus (MN908947.3) , with a DYKDDDDK tag.
Cat #: LTP-V001
Host: Human cells
RefSeq: MN908947.3; QHD43423.2;
Molecular Weight: 49.4 kDa
Applications: Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies
Quantity: 50ug, >Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg)
Purity: >90% by SDS-PAGE gel and Coomassie Blue staining
Formulation: Protein formulated in a solution of 0.1M glycine, 50 mM Tris.Cl, pH7.4, 150mM NaCl
Background:The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. The SARS-CoV-2 spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S RBD protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV-2 (2019-nCoV) as in recent COVID-19 outbreak.
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Purity: Purity: >90% by SDS-PAGE gel and Coomassie Blue staining