Product Name | Transdermal Peptide TD1, ACSSSPSKHCG, acetylated, amidated |
Product Quantity | 5.0 mg |
Catalog Number | LT110202 |
Molecular Weight | 1102.2 |
Formula | C40H64N14O16S2 |
Sequence | Ac- ACSSSPSKHC G -CONH2, disulfide bridges:C2-C10, Ac- Ala - Cys - Ser - Ser - Ser - Pro - Ser - Lys - His - Cys - Gly -CONH2 |
Purity | 95.649% |
Product Description | The short synthetic peptide ACSSSPSKHCG (TD1) and oligoarginine (R8) have been shown to facilitate efficient bio-macromolecule delivery through intact skin. Co-administration of the peptide and insulin to the abdominal skin of diabetic rats results in elevated systemic levels of insulin and suppresses serum glucose levels. This peptide creates a transient opening in the skin barrier to enable macromolecular medicines to reach systemic circulation.
The delivery system was applied to treat melisma. Treatment with a cream formulation containing the transdermal peptide co-administered with other agents resulted in measurable inhibition of melanin production and melanocyte apoptosis. After four weeks application, patients demonstrated a significant lightening of facial hypermelanosis lesions and almost wholly restored dark lesions to normal skin color after 12 weeks. These innovative peptide technologies give the patients for even, young and healthy looking skin. Its topical application induces restoration of the skin’s most important structural dermal components. |
Scientific Background | Transdermal Peptide TD1, ACSSSPSKHCG, acetylated, amidated is a 11-residue synthetic peptide with the sequence Ala-Cys-Ser-Ser-Ser-Pro-Ser-Lys-His-Cys-Gly. N-terminal acetylation neutralizes the terminal alpha-amino group; C-terminal amidation removes the terminal carboxylate charge. The sequence contains 2 cysteine residues, providing potential thiol/disulfide chemistry when the thiol is available. These sequence-derived properties describe the reagent chemically; no specific receptor, enzyme, pathway, disease association, or biological activity is assigned without product-specific experimental evidence. |
Research Applications | - thiol-selective conjugation or immobilization studies
- LC-MS/HPLC analytical method development
- sequence-specific assay controls
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Experimental Notes | Sequence-derived chemical properties support reagent selection and experimental planning but do not establish biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended experimental conditions. |
