Product Name | HS-cR10 |
Product Quantity | 5 mg |
Catalog Number | LT8154 |
Molecular Weight | C86H168N47O20S [M + H]+, 2213; [M + 2H]2+,1107; found, 1108 |
Formula | C86H168N47O20S |
Sequence | C-(mini-PEG)-(mini-PEG)-KRrRrRrRrRrE, C-Terminal: Amidation, Lower case letter r: D-Arg, KE side chain amide cyclization 
|
Purity | >95% |
Product Description | HS-cR10 is a cell penetrating peptide. Using cytochrome c (Cyt c) and the green fluorescent protein (GFP) as models, Joomyung V. Jun et al. generated protein conjugates modified with diverse domains for cellular delivery that include a small molecule, targeting and cell-penetrating peptides (CPPs), and a large polysaccharide. HS-cR10 was conjugated to Cyt c and GFP and the proteins were delivered into the cytosol of live mammalian cells. 
Reference: https://pubs.acs.org/doi/10.1021/jacs.2c11325;
...HS-cR10 was initially synthesized in-house and later obtained on a larger scale from LifeTein (Somerset, NJ)...
See details about the cell penetrating peptides: https://www.lifetein.com/Cell_Penetrating_Peptides.html |
Scientific Background | HS-cR10 is a 12-residue synthetic peptide with the sequence Lys-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Glu. C-terminal amidation removes the terminal carboxylate charge. The sequence contains 1 Lys and 10 Arg residues, contributing cationic character. These sequence-derived properties describe the reagent chemically; no specific receptor, enzyme, pathway, disease association, or biological activity is assigned without product-specific experimental evidence. |
Research Applications | - LC-MS/HPLC analytical method development
- sequence-specific assay controls
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Experimental Notes | Sequence-derived chemical properties support reagent selection and experimental planning but do not establish biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended experimental conditions. |
