Product Name | (5-FAM)-GISYGAKKRRQRRRAHQ-Cys(TAMRA) |
Product Quantity | 1mg |
Catalog Number | LT8228 |
Category | Peptide |
Sequence | (5-FAM)-GISYGAKKRRQRRRAHQ-Cys(TAMRA), HIV TAT (48-60) variant from the core sequence GRKKRRQRRRPPQ |
Purity | >95 % |
Modifications | This is an FAM/TAMRA double labeled cell-penetrating peptides (CPPs) derived from the human immunodeficient virus (HIV)-1 Tat protein residue 48-60. It has been used to deliver exogenous macromolecules into cells in a non-disruptive way. GRKKRRQRRRPPQ; Cy3 Labeled R8 CPP variant Cy3-AAARKKRRQRRRAAA and Cy3-GISYGAKKRRQRRRAHQ are available. |
Scientific Background | (5-FAM)-GISYGAKKRRQRRRAHQ-Cys(TAMRA) is a 17-residue synthetic peptide with the sequence Gly-Ile-Ser-Tyr-Gly-Ala-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-His-Gln. FAM provides a fluorescent label for optical detection; TAMRA provides a fluorescent label for optical detection. The sequence contains 2 Lys and 5 Arg residues, contributing cationic character. These sequence-derived properties describe the reagent chemically; no specific receptor, enzyme, pathway, disease association, or biological activity is assigned without product-specific experimental evidence. |
Research Applications | - fluorescence-based detection
- binding or localization assay development
- LC-MS/HPLC analytical method development
- sequence-specific assay controls
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Experimental Notes | Sequence-derived chemical properties support reagent selection and experimental planning but do not establish biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended experimental conditions. |
