Catalog Number:
Biotin, Ahx linker, free acid; The majority of Staphylococcus aureus virulence- and colonization-associated surface proteins contain a pentapeptide recognition motif (LPXTG). This motif can be recognized and cleaved by sortase A (SrtA) which is a membrane-bound transpeptidase. LPTEG-tagged probes and proteins can be conjugated using sortase A in a single step to glycines naturally exposed at the cell surface.

Significance and functions of the LPETGS motif:

  1. Protein Targeting: The LPETGS motif serves as a signal sequence that directs proteins to specific cellular organelles. For example, it is recognized by the signal recognition particle (SRP) during the cotranslational targeting of proteins to the endoplasmic reticulum, where they are synthesized and folded.
  2. ER Localization: Proteins containing the LPETGS motif are often translocated into the endoplasmic reticulum, a crucial organelle involved in protein synthesis, modification, and quality control. This motif aids in the proper localization of these proteins within the ER.
  3. Mitochondrial Targeting: In some cases, the LPETGS motif is involved in the targeting of proteins to the mitochondria, which are responsible for energy production within the cell. This motif plays a role in ensuring that the proteins are directed to the mitochondrial outer membrane.
  4. Protein Folding and Quality Control: Proteins that contain the LPETGS motif may undergo specific folding and quality control processes within the ER. This helps ensure that only properly folded and functional proteins are allowed to exit the ER and reach their final cellular destinations.
  5. Biomedical Implications: Understanding the LPETGS motif's role in protein targeting and localization is of great significance in biomedical research. Researchers study this motif to gain insights into various diseases and conditions where protein trafficking and localization are disrupted, such as certain types of congenital disorders and neurodegenerative diseases.

Other related LPETG products:

Cat. No
Product Name
5467 Biotin-Ahx-LPETGS-NH2 LPXTG motif in Sortase A (Srt) from Staphylococcus aureus, amidation $280
add to cart
6142 Biotin-Ahx-LPETGS-COOH LPXTG motif in Sortase A (Srt) from Staphylococcus aureus, free acid $280
add to cart
5716 Biotin-AALPETG*G, G* is 2-hydroxyacetic acid 2-hydroxyacetic acid modified $320
add to cart
6271 FITC-Ahx-LPETGS FITC labeling of peptides by SrtA $280
add to cart
6272 Rhodamine B-Ahx-LPETGS Rhodamine labeling of peptides by SrtA $450
add to cart
6148 Biotin-Ahx-LPETG-NH2 LPETG motif $280
add to cart
5747 Biotin-ALPETGG LPETG motif, SrtA $280
add to cart
5989 Cy5-Cys-HHHHHHHHHLPETGG Cy5 Labeling $480
add to cart
35816 VC-PAB-MMAE-LPETGG Monomethyl auristatin E (MMAE) conjugate $420
add to cart
  • 6 Units in Stock

Ask a Question


Add to Cart:
LifeTein LifeTein provides custom peptide synthesis service, recombinant proteins, peptides, cytokines, custom antibody service and custom protein service. LifeTein is the world leader in fast peptide synthesis service with lab facility located in New Jersey USA. LifeTein Peptide 100 Randolph Road, Suite 2D, Somerset USA New Jersey 08873
Copyright © 2024 Powered by LifeTein