| Linker-Toxin SET, this set is made by Monomethyl auristatin E (MMAE) conjugated to the lysosomally cleavable Gly3-vc-PAB linker. MMAE, a potent tubulin inhibitor, is a toxin payload in the antibody-drug conjugate. The sortase recognition sequence, LPXTG (for Staphylococcus aureus sortase A) or LPXTA (for Streptococcus pyogenes sortase A), can be appended to a variety of probes such as fluorophores, biotin, or even to other proteins. The protein to be labeled acts as a nucleophile by attacking the intermediate formed between the probe containing the LPXTG/A motif and the sortase enzyme. Molecular Formula: C101H161N19O27S; Formula Weight: 2105.57 |
