VC-PAB-MMAE-LPETGG

Catalog Number:
35816: MMAE-PAB-Val-Cit-(thioether linker)-Ahx-LPETGG
Category:
Peptide
Sequence:

MMAE-PAB-Val-Cit-(thioether linker)-Ahx-LPETGG

Peptide C-Ahx-LPETGG conjugated with MMAE-PAB-Val-Cit-Maleimide via Maleimide-thiol reaction.

Modifications:
Quantity:
2 mg
Purity:
>95%
Peptide Info:
Linker-Toxin SET, this set is made by Monomethyl auristatin E (MMAE) conjugated to the lysosomally cleavable Gly3-vc-PAB linker. MMAE, a potent tubulin inhibitor, is a toxin payload in the antibody-drug conjugate. The sortase recognition sequence, LPXTG (for Staphylococcus aureus sortase A) or LPXTA (for Streptococcus pyogenes sortase A), can be appended to a variety of probes such as fluorophores, biotin, or even to other proteins. The protein to be labeled acts as a nucleophile by attacking the intermediate formed between the probe containing the LPXTG/A motif and the sortase enzyme. Molecular Formula: C101H161N19O27S; Formula Weight: 2105.57
Notes:

Other related LPETG products:

Cat. No
Product Name
Applications
Price
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LPETG LPXTG motif
5467 Biotin-Ahx-LPETGS-NH2 LPXTG motif in Sortase A (Srt) from Staphylococcus aureus, amidation $280
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6142 Biotin-Ahx-LPETGS-COOH LPXTG motif in Sortase A (Srt) from Staphylococcus aureus, free acid $280
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5716 Biotin-AALPETG*G, G* is 2-hydroxyacetic acid 2-hydroxyacetic acid modified $320
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6271 FITC-Ahx-LPETGS FITC labeling of peptides by SrtA $280
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6272 Rhodamine B-Ahx-LPETGS Rhodamine labeling of peptides by SrtA $450
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6148 Biotin-Ahx-LPETG-NH2 LPETG motif $280
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5747 Biotin-ALPETGG LPETG motif, SrtA $280
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5989 Cy5-Cys-HHHHHHHHHLPETGG Cy5 Labeling $480
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35816 VC-PAB-MMAE-LPETGG Monomethyl auristatin E (MMAE) conjugate $420
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  • 8 Units in Stock
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