Recombinant Human Transmembrane protease serine 2 TMPRSS2

$800.00

Description:Recombinant Human Transmembrane protease serine 2 (TMPRSS2) Protein

                                       

Product: Recombinant protein of the extracellular domain (Met 109-Gly492) of Homo sapiens transmembrane protease, serine 2 (TMPRSS2), with a polyhistidine tag at its c-terminus

                         

Cat #: LTP-V017

             

Host: Human 293 cells

                                       

RefSeq: NM_005656.4; NP_005647.3; UniProt#: O15393; Gene ID: 7113;

                                       

Molecular Weight: The amino acid sequences of recombinant protein was derived from accession# O15393-1 (M109-G492), fused to a polyhistidine tag. The predicted MW of this product is 49 kDa on the reduced SDS-PAGE.

                         

Applications: Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!

Background: Homo sapiens transmembrane protease, serine 2 (TMPRSS2) encodes a protein that belongs to the serine protease family. Serine proteases are known to be involved in many physiological and pathological processes. Some coronavirus viruses, including HCoV-229E, MERS-CoV, SARS-CoV, and SARS-CoV-2 virus, are found to use this protein for the entry into host cells via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry. SARS-CoV-2 uses the SARS-CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming. A TMPRSS2 inhibitor approved for clinical use blocked entry and might constitute a treatment option. The viral S glycoprotein is cleaved by TMPRSS2, thus facilitating viral activation and representing one of the essential host factors for SARS-CoV-2 pathogenicity.

                         

Quantity: 50ug, Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg).

                         

Purity: >90% by SDS-PAGE gel and Coomassie Blue staining

                         

Formulation: Protein formulated @ 0.19 mg/mL in a solution of PBS, pH7.2;

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