Recombinant Human Transmembrane protease serine 2 TMPRSS2

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Description:Recombinant Human Transmembrane protease serine 2 (TMPRSS2) Protein


Product: Recombinant protein of the extracellular domain (Met 109-Gly492) of Homo sapiens transmembrane protease, serine 2 (TMPRSS2), with a polyhistidine tag at its c-terminus


Cat #: LTP-V017


Host: Human 293 cells


RefSeq: NM_005656.4; NP_005647.3; UniProt#: O15393; Gene ID: 7113;


Molecular Weight: The amino acid sequences of recombinant protein was derived from accession# O15393-1 (M109-G492), fused to a polyhistidine tag. The predicted MW of this product is 49 kDa on the reduced SDS-PAGE.


Applications: Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!

Background: Homo sapiens transmembrane protease, serine 2 (TMPRSS2) encodes a protein that belongs to the serine protease family. Serine proteases are known to be involved in many physiological and pathological processes. Some coronavirus viruses, including HCoV-229E, MERS-CoV, SARS-CoV, and SARS-CoV-2 virus, are found to use this protein for the entry into host cells via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry. SARS-CoV-2 uses the SARS-CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming. A TMPRSS2 inhibitor approved for clinical use blocked entry and might constitute a treatment option. The viral S glycoprotein is cleaved by TMPRSS2, thus facilitating viral activation and representing one of the essential host factors for SARS-CoV-2 pathogenicity.


Quantity: 50ug, Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg).


Purity: >90% by SDS-PAGE gel and Coomassie Blue staining


Formulation: Protein formulated @ 0.19 mg/mL in a solution of PBS, pH7.2;

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LifeTein Recombinant Human Transmembrane protease serine 2 TMPRSS2 Protein LTP-V017

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