Peptide Library: SARS-CoV-2 Receptor Binding Domains

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coronavirus peptide library

Overlapping Peptide Library: The SARS-CoV-2 Receptor Binding Domain is divided in to several fragments (15 amino acids) that overlap (5 amino acids). The resulting overlapping peptide libraries can then be used for processes including continuous and linear epitope mapping, antibody screening and characterization.

Reference 1: A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV, Science 03 Apr 2020:eabb7269, DOI: 10.1126/science.abb7269

Supplementary Materials

LifeTein can help in your research with custom peptide synthesis of the following specific proteins: SARS-CoV-2 Receptor Binding Domains, SARS-CoV-2 Nucleocapsid Fragments, T-cell and B-cell Epitopes of SARS-CoV-2, Fusion Inhibitors Targeting HR1 Domain of the SARS-CoV-2 Spike Proteins, Inhibitors of SARS-CoV-2 Mpro/3CLpro/C30 Endopeptidase, ACE2 Inhibitors and Substrates, and AT2 Receptor Agonists and Antagonists.

Pool of 22 peptides derived from a peptide design (15mers with 5 aa overlap) through the receptor binding domain of S1 protein.

Modifications: N-Terminal: Biotin Labeling

Amount: 1mg per peptide

Purity: 95%

Delivery Format: Freeze dried powder

Application(s): Antibody screening, T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, Cellular immune response

Indication(s)/Topic(s): Covid-19, Infection, Respiratory infection

Delivery Time: In Stock

SARS-CoV-2 Receptor Binding Domains Overlapping Peptide Pools:

  • QPTESIVRFPNITNL
  • NITNLCPFGEVFNAT
  • VFNATRFASVYAWNR
  • YAWNRKRISNCVADY
  • CVADYSVLYNSASFS
  • SASFSTFKCYGVSPT
  • GVSPTKLNDLCFTNV
  • CFTNVYADSFVIRGD
  • VIRGDEVRQIAPGQT
  • APGQTGKIADYNYKL
  • YNYKLPDDFTGCVIA
  • GCVIAWNSNNLDSKV
  • LDSKVGGNYNYLYRL
  • YLYRLFRKSNLKPFE
  • LKPFERDISTEIYQA
  • EIYQAGSTPCNGVEG
  • NGVEGFNCYFPLQSY
  • PLQSYGFQPTNGVGY
  • NGVGYQPYRVVVLSF
  • VVLSFELLHAPATVC
  • PATVCGPKKSTNLVK
  • TNLVKNKCVNFNFNG
coronavirus peptide pool

The key receptor binding domain (residues 319-541) is highlighted in yellow. Variable amino acid residues between SARS-CoV-2 and SARS-CoV are highlighted in cyan. Tyr 489, Asn 487, Gln 493, Tyr 505 are important for ACE2 binding.


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