Overlapping Peptide Library: The SARS-CoV-2 Receptor Binding Domain is divided in to 4 fragments of 20 amino acids per peptide. The resulting overlapping peptide libraries can then be used for processes including continuous and linear epitope mapping, antibody screening and characterization.
Reference 1: A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV, Science 03 Apr 2020:eabb7269, DOI: 10.1126/science.abb7269
LifeTein can help in your research with custom peptide synthesis of the following specific proteins: SARS-CoV-2 Receptor Binding Domains, SARS-CoV-2 Nucleocapsid Fragments, T-cell and B-cell Epitopes of SARS-CoV-2, Fusion Inhibitors Targeting HR1 Domain of the SARS-CoV-2 Spike Proteins, Inhibitors of SARS-CoV-2 Mpro/3CLpro/C30 Endopeptidase, ACE2 Inhibitors and Substrates, and AT2 Receptor Agonists and Antagonists.
Pool of 4 peptides derived from a peptide design (20 mers without overlapping) through the receptor binding domain of S1 protein.
Modifications: N-Terminal: Biotin Labeling
Amount: 1mg per peptide
Delivery Format: Freeze dried powder
Application(s): Antibody screening, T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, Cellular immune response
Indication(s)/Topic(s): Covid-19, Infection, Respiratory infection
Delivery Time: In Stock
SARS-CoV-2 Receptor Binding Domains Peptide Pools:
- gcviawnsnn ldskvggnyn
- ylyrlfrksn lkpferdist
- eiyqagstpc ngvegfncyf
- plqsygfqpt ngvgyqpyrv
The key receptor binding domain (residues 319-541) is highlighted in yellow. Variable amino acid residues between SARS-CoV-2 and SARS-CoV are highlighted in cyan. Tyr 489, Asn 487, Gln 493, Tyr 505 are important for ACE2 binding.