Product Name | CSPGAKVRC-NH2 |
Product Quantity | 4mg |
Catalog Number | 5674 |
Category | UNO Peptide |
Sequence | CSPGAKVRC-NH2 |
Cat. No | Product Name |
8232 | mUNO Peptide |
8233 | MACTIDE-Verteporfin |
8234 | MACTIDE |
5674 | CSPGAKVRC-NH2 |
Product Description | 
UNO selectively targets Mannose Receptor (CD206/MRC1)-expressing Tumor-Associated Macrophages (TAMs), contributing to the suppression of tumor growth, angiogenesis, metastasis, and relapse. Intriguingly, FAM-labeled UNO (FAM-UNO) homes in on TAMs in various cancer models, including breast carcinoma, melanoma, glioma, and gastric carcinoma. Ex vivo organ imaging demonstrates FAM-UNO's exceptional ability to accumulate in sentinel lymph nodes, hinting at its potential in diagnostic imaging and therapeutic targeting of TAMs in solid tumors. It was found that the linear CSPGAKVRC and CSPGAK bind to CD206. |
Scientific Background | CSPGAKVRC-NH2 is a 9-residue synthetic peptide with the sequence Cys-Ser-Pro-Gly-Ala-Lys-Val-Arg-Cys. C-terminal amidation removes the terminal carboxylate charge. The sequence contains 2 cysteine residues, allowing thiol/disulfide chemistry when available. These sequence-derived properties describe the reagent chemically; no specific biological activity is assigned without product-specific experimental evidence. |
Research Applications | - thiol-selective conjugation or immobilization studies
- LC-MS/HPLC analytical method development
- sequence-specific assay controls
|
Experimental Notes | Sequence-derived chemical properties support reagent selection and experimental planning but do not establish biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended conditions. |
