Biotin-Neurokinin B

Product Name
Biotin-Neurokinin B
Product Quantity
5mg
Catalog Number
LT1099
Molecular Weight
1436.74
Formula
C65H93N15O16S3
Sequence
Biotin-Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2
CAS#
1926163-17-8
Related Product

Neurokinin A: HKTDSFVGLM

Neurokinin A (4-10): DSFVGLM

Neurokinin B: DMHDFFVGLM

Biotin-Neurokinin A: Biotin-HKTDSFVGLM

Biotin-Neurokinin B: Biotin-DMHDFFVGLM

Substance P: RPKPQQFFGLM

Physalaemin: pGlu-ADPNKFYGLM

Kassinin: DVPKSDQFVGLM

Eledoisin: pGlu-PSKDAFIGLM

Eledoisin Related Peptide: KFIGLM


Neuropeptides
Product Description
There is growing evidence that neurokinin B (NKB) is a key modulator of gonadotropin-releasing hormone (GnRH) secretion and, hence, of reproductive function in men and women. Loss-of-function mutations in the genes encoding NKB (TAC3) and the neurokinin-3 receptor (TAC3R) result in hypogonadotropic pubertal delay.
Scientific Background

Biotin-Neurokinin B is a synthetic research peptide in the tachykinin neuropeptide family. Substance P, neurokinin A, and neurokinin B are mammalian tachykinins that preferentially interact with NK1, NK2, and NK3 receptors, respectively. Their shared C-terminal tachykinin motif is important for receptor activation, while N-terminal truncation, substitutions, and labels can alter affinity, selectivity, and stability.

Research Applications
  • tachykinin receptor binding and activation assays
  • NK1/NK2/NK3 pharmacology
  • calcium or phospholipase signaling studies
  • fragment and analog structure-activity comparisons
Experimental Notes

The exact sequence, species, residue range, terminal state, labels, stereochemistry, and post-translational modifications should be considered when comparing this reagent with the native peptide. Receptor potency and assay behavior should be validated in the intended experimental system.

Selected References
  1. Mammalian tachykinin receptor pharmacology
  2. Tachykinin peptide/receptor selectivity
  • 5 Units in Stock
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