Biotin-Neuromedin B

Biotin-Neuromedin B is a synthetic research peptide in the neuromedin B / bombesin-related peptide family. Neuromedin B is a mammalian bombesin-related peptide that preferentially activates the neuromedin B receptor (NMBR), a G-protein-coupled receptor linked to phospholipase activation, intracellular calcium mobilization, and protein kinase C signaling. Sequence substitutions or labels can change receptor affinity and should be evaluated relative to the native peptide.

• NMB receptor binding assays
• bombesin-receptor pharmacology
• calcium-mobilization studies
• neuromedin B analog comparisons

The exact sequence, species, residue range, terminal state, labels, stereochemistry, and post-translational modifications should be considered when comparing this reagent with the native peptide. Receptor potency and assay behavior should be validated in the intended experimental system.

1. Neuromedin B and its receptor
2. Molecular basis for NMB receptor selectivity