Amylin, rat

Amylin is a peptide that displays 50% homology with calcitonin gene-related peptide (CGRP). Amylin is colocalized with somatostatin in endocrine cells of the gastric fundus. In isolated mouse stomach. amylin caused a concentration-dependent decrease in acid secretion. In rat fundic segments. amylin and CGRP each caused a concentration-dependent increase in somatostatin and a decrease in histamine secretion. Rat/mouse Amylin differs from the human version in 6 amino acids: H18R, F23L, A25P, I26V, S28P and S29P (first letter is the amino acid of the human sequence). Unlike the human IAPP (Amylin), rat Amylin does not form amyloid fibers. CAS registry number: 124447-81-0