Product Name | Amylin(1-37), human |
Product Quantity | 1mg |
Catalog Number | LT0945 |
Molecular Weight | 3903.4 |
Formula | C165H261N51O55S2 |
Sequence | Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2, disulfide bridge 2-7 |
Product Purity | 98.026% |
Product Description | This 37 amino acid polypeptide is secreted from the b cells of the pancreas and structurally related to calcitonin. It has anoretic effects in rats. It may be responsible for the etiology of insulin resistance of type II diabetes mellitus through its modulation of peripheral effects of insulin. It blocks the activation of glycogen synthase by insulin. |
Scientific Background | Amylin(1-37), human is a synthetic research peptide in the amylin peptide family. Amylin is a 37-residue pancreatic peptide. Human and rodent amylin differ in sequence and aggregation propensity, so species identity and modifications are important experimental variables in receptor, aggregation, and analytical studies. |
Research Applications | - amylin aggregation studies
- amylin receptor research
- species-dependent structure-function comparisons
- analytical peptide studies
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Experimental Notes | The exact sequence, residue range, species, terminal state, and chemical modifications should be matched to the intended assay. Fragmentation or processing can materially alter receptor selectivity, potency, aggregation, or enzymatic behavior. |
Selected References | - Amylin peptide literature search
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