Catalog Number | LT8772 |
Product Name | TAT-NSF700 Fusion Peptide |
Product Quantity | 1 mg |
Sequence | YGRKKRRQRRR-GGG-LLDYVPIGPRFSNLVLQALLVL |
Molecular Weight | 4167.2 |
Purity | ≥95% |
Scientific Background | TAT-NSF700 is a cell-permeable fusion peptide combining the HIV Tat transduction sequence with an NSF-derived inhibitory region. Published studies reported that this fusion construct inhibits N-ethylmaleimide-sensitive factor-dependent exocytosis and reduces thrombin-stimulated endothelial exocytosis, providing a tool for studying NSF-dependent vesicle fusion and regulated secretion. |
Research Applications | - NSF-dependent exocytosis studies
- endothelial secretion research
- cell-penetrating peptide delivery studies
- vesicle-fusion experiments
|
Experimental Notes | The Tat domain promotes cellular delivery and can itself influence uptake and intracellular distribution. Tat-only and sequence-control peptides are useful when attributing effects to the NSF700 region. |
Selected References | - A Novel Class of Fusion Polypeptides Inhibits Exocytosis
- A Novel Inhibitor of N-Ethylmaleimide-Sensitive Factor Decreases Leukocyte Trafficking and Peritonitis
|
