TAT-GluR23A Fusion Peptide

YGRKKRRQRRRAKEGANVAG is a cell-permeable TAT-GluR23A fusion peptide designed as a phosphorylation-deficient control for the GluR2-derived GluR23Y endocytosis peptide. In the GluR2 segment, key tyrosines are replaced with alanines, removing phosphorylation sites implicated in regulated AMPA-receptor trafficking. The peptide is therefore useful as a matched control in studies of GluR2 tyrosine phosphorylation, AMPA receptor endocytosis and synaptic plasticity.

• AMPA receptor trafficking controls
• GluR2 phosphorylation studies
• synaptic plasticity research
• cell-penetrating control peptide studies

TAT-GluR23A is a mutant control construct, not a guarantee of complete biological inactivity. Its use is most informative when tested in parallel with the corresponding TAT-GluR23Y peptide under matched conditions.

1. Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD
2. α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Subtype Glutamate Receptor Endocytosis Is Essential for N-Methyl-D-aspartate-induced Neuronal Apoptosis