Catalog Number | LT8850 |
Product Name | Tat-GluR2-3Y Scrambled Control Peptide |
Product Quantity | 1 mg |
Sequence | YGRKKRRQRRRVYKYGGYNE |
CAS Number | 1404188-94-8 |
Molecular Weight | 2634.1 |
Formula | C115H185N43O29 |
Purity | ≥95% |
Scientific Background | YGRKKRRQRRRVYKYGGYNE is a scrambled control peptide associated with the cell-permeable Tat-GluR2-3Y experimental system used to study AMPA-receptor trafficking. It retains the HIV Tat-derived polybasic delivery segment while scrambling the GluR2-derived tyrosine-containing portion. The reagent is useful as a matched sequence control when evaluating sequence-dependent effects of Tat-GluR2-3Y on AMPA-receptor endocytosis and synaptic-plasticity paradigms. |
Research Applications | - Tat-GluR2-3Y control experiments
- AMPA receptor trafficking studies
- synaptic plasticity research
- cell-penetrating peptide controls
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Experimental Notes | A scrambled control should not be assumed to be universally biologically inert. Use matched concentration, vehicle and exposure conditions and interpret any activity directly in the experimental system. |
Selected References | - Amygdala depotentiation and fear extinction
- Disruption of AMPA receptor endocytosis impairs the extinction, but not acquisition of learned fear
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