Catalog Number | LT8811 |
Product Name | Small Humanin-Like Peptide 4 (SHLP4), Human |
Product Quantity | 1 mg |
Sequence | MLEVMFLVNRRGKICRVPFTFFNLSL |
Molecular Weight | 3132.0 |
Purity | ≥95% |
Scientific Background | SHLP4 is a 26-residue small humanin-like peptide encoded in the mitochondrial 16S rRNA region. In the original SHLP functional study, SHLP4 displayed a distinct cellular phenotype from several other family members and promoted proliferation in NIT-1 pancreatic beta-cell-derived cells under the reported experimental conditions. This sequence therefore provides a useful reagent for comparing mitochondrial-derived peptide signaling and sequence-dependent SHLP activity. |
Research Applications | - SHLP family structure-function studies
- mitochondrial-derived peptide research
- cell-proliferation assays
- mitochondrial signaling studies
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Experimental Notes | The reported proliferative effect was observed in specific experimental cell systems. SHLP4 activity should be established independently in other cell types or assay formats. |
Selected References | - Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers
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