Description: Recombinant Human ACE2 Protein(H374N, and H378N)
Product: Recombinant protein of the extracellular domain (Gln18-Asp615) of Homo sapiens angiotensin converting enzyme 2 (ACE2), transcript variant 2 (NM_021804), with H374N, H378N point mutation, and a Human IgG1 Fc tag.
Host: Human cells
RefSeq: NM_021804; NP_068576; UniProt#: Q9BYF1; GeneID: 59272;
Molecular Weight: 97.8 kDa
Applications: Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Background: The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008].
Quantity: 50ug, >Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg)
Purity: >90% by SDS-PAGE gel and Coomassie Blue staining
Formulation: Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
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