PLP (139-151) C140S

This serine-substituted PLP(139-151) analog replaces Cys140 with Ser. It is a heteroclitic/altered peptide ligand used in experimental autoimmune encephalomyelitis studies and can induce severe acute disease in susceptible SJL mice.

• experimental autoimmune encephalomyelitis / neuritis
• multiple-sclerosis and demyelination research
• myelin epitope mapping
• T-cell and antibody recognition studies

Species assignment, residue boundaries, substitutions, terminal caps and affinity labels are part of the exact reagent identity. Use the matching species/epitope form when reproducing published autoimmune-myelin models.

1. Selected peer-reviewed myelin/autoimmunity study