PLP (178-191) Peptide

NTWTTCQSIAFPSK corresponds to residues 178-191 of myelin proteolipid protein (PLP). This peptide is a well-characterized encephalitogenic T-cell determinant used in experimental autoimmune encephalomyelitis models. Published studies identify PLP(178-191) as an encephalitogenic peptide in SJL/J mice and also use the exact sequence in additional mouse strains and mechanistic studies of myelin-reactive immune responses.

• experimental autoimmune encephalomyelitis research
• myelin-reactive T-cell studies
• PLP epitope research
• neuroimmunology assay development

Encephalitogenicity is strain- and experimental-context dependent. The peptide should not be described as a universal multiple-sclerosis antigen or assigned human disease activity solely from mouse EAE studies.

1. Sequence 104-117 of myelin proteolipid protein is a cryptic encephalitogenic T cell determinant for SJL/J mice
2. Experimental Autoimmune Encephalomyelitis in Mice