Catalog Number | LT8886 |
Product Name | Pep-1-Cysteamine Cell-Penetrating Peptide |
Product Quantity | 1 mg |
Sequence | Ac-KETWWETWWTEWSQPKKKRKV-cysteamine |
CAS Number | 863608-35-9 |
Molecular Weight | 2949.5 |
Formula | C140H202N36O33S |
Purity | ≥95% |
Scientific Background | Ac-KETWWETWWTEWSQPKKKRKV-cysteamine is a Pep-1-derived amphipathic cell-penetrating peptide containing a tryptophan-rich hydrophobic domain, a basic SV40-NLS-derived region and a C-terminal cysteamine group. Pep-1 constructs have been used for noncovalent intracellular delivery of proteins and other macromolecules. The cysteamine-containing form provides a chemically defined variant for delivery and membrane-interaction research. |
Research Applications | - cell-penetrating peptide delivery
- protein and macromolecule transport studies
- amphipathic peptide membrane research
- Pep-1 structure-function studies
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Experimental Notes | Delivery efficiency depends on cargo, peptide:cargo ratio, cell type and formulation. The C-terminal cysteamine is part of this product's chemical identity and should be retained in comparisons. |
Selected References | - Re-evaluating the role of strongly charged sequences in amphipathic cell-penetrating peptides: a fluorescence study using Pep-1
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