Product Name | Pep-1 |
Product Quantity | 5mg |
Catalog Number | LT2031 |
Molecular Weight | 2848.29 |
Formula | C136H195N35O33 |
Sequence | Lys-Glu-Thr-Trp-Trp-Glu-Thr-Trp-Trp-Thr-Glu-Trp-Ser-Gln-Pro-Lys-Lys-Lys-Arg-Lys-Val |
Product Description | PEP-1 peptide, which has 21 amino acid residues, is a peptide carrier for the noncovalent delivery of proteins into cells. it consists of three domains: (a) a hydrophobic tryptophan-rich motif containing five tryptophan residues (KETW WETWWTEW); (b) a hydrophilic lysine-rich domain (KKKRKV) derived from the nuclear localization sequence (NLS) of simian virus 40 (SV-40) large T antigen; (c) a spacer domain (SQP), separating the two domains mentioned above, containing a proline residue, which improves the flexibility and the integrity of both the hydrophobic and the hydrophilic domains. |
Scientific Background | Pep-1 is a 21-residue synthetic peptide with the sequence Lys-Glu-Thr-Trp-Trp-Glu-Thr-Trp-Trp-Thr-Glu-Trp-Ser-Gln-Pro-Lys-Lys-Lys-Arg-Lys-Val. The sequence contains 5 Lys and 1 Arg residues, contributing cationic character; contains 5 aromatic residues that can contribute to hydrophobic or aromatic interactions. These sequence-derived properties describe the reagent chemically; no specific receptor, enzyme, pathway, disease association, or biological activity is assigned without product-specific experimental evidence. |
Research Applications | - LC-MS/HPLC analytical method development
- sequence-specific assay controls
|
Experimental Notes | Sequence-derived chemical properties support reagent selection and experimental planning but do not establish biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended experimental conditions. |
