Catalog Number | LT8993 |
Product Name | OVA (323-339), C-Terminal Amide |
Product Quantity | 1 mg |
Sequence | ISQAVHAAHAEINEAGR-NH2 |
Molecular Weight | 1773.1 |
Formula | C74H121N27O24 |
Purity | ≥95% |
Scientific Background | ISQAVHAAHAEINEAGR-NH2 is the amidated form of the OVA(323-339) MHC class-II epitope. OVA(323-339) contains overlapping CD4 T-cell recognition registers and is a standard antigen in murine helper-T-cell models. Amidation provides a terminally modified reagent for comparative antigen-presentation and peptide-stability studies. |
Research Applications | - MHC class II peptide presentation
- OT-II/DO11.10 T-cell studies
- terminal-modification comparisons
- CD4 T-cell immunology
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Experimental Notes | Amidation changes the C-terminal charge and creates a distinct chemical species from free-acid OVA(323-339). LifeTein current web specification reports MW 1773.1, while an older technical sheet reports approximately 1774.0; the current catalog value is retained here and the discrepancy should not be silently averaged. |
Selected References | - DO11.10 and OT-II T Cells Recognize a C-Terminal Ovalbumin 323–339 Epitope
- DNA Vaccines, Combining Form of Antigen and Method of Delivery to Raise a Spectrum of IFN-γ and IL-4-Producing CD4+ and CD8+ T Cells
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