Product Name | Octreotide Acetate |
Product Quantity | 10mg |
Catalog Number | LT1938 |
Molecular Weight | 1019.2 |
Formula | C49H66N10O10S2 |
Sequence | D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-Ol (Disulfide bridge Cys2-Cys7), Octreotide Acetate is the acetate salt of a synthetic long-acting cyclic octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin. Octreotide is a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Similar to somatostatin, this agent also suppresses the luteinizing hormone response to gonadotropin-releasing hormone, decreases splanchnic blood flow, and inhibits the release of serotonin, gastrin, vasoactive intestinal peptide (VIP), secretin, motilin, pancreatic polypeptide, and thyroid stimulating hormone. |
Product Description | Octreotide (SMS 201-995) is a somatostatin analog that is three times more potent than the native hormone in inhibiting the secretion of growth hormone. |
Scientific Background | Octreotide Acetate is a synthetic research peptide in the octreotide somatostatin analog family. Octreotide is a cyclic octapeptide somatostatin analog with high affinity particularly for somatostatin receptor subtype sst2 and relevant activity at sst5. It is widely used as a pharmacological ligand for somatostatin-receptor binding, signaling, internalization, and subtype-expression studies. |
Research Applications | - somatostatin receptor binding assays
- sst2/sst5 pharmacology
- receptor internalization studies
- somatostatin analog comparisons
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Experimental Notes | The exact sequence, residue range, species, stereochemistry, terminal state, labels, and other modifications can materially affect activity. Match the supplied construct to the intended assay and published reference context. |
Selected References | - Somatostatin receptor subtypes and octreotide binding
- Radiolabeled octreotide derivatives and sst2 internalization
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