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| Human GITR/TNFRSF18 Protein (LTP10435) |
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| LTP10435 |
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| 100ug |
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$406 In stock |
| GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. |
| Recombinant Human GITR/TNFRSF18 Protein is expressed from Expi293 with hFc tag at the C-terminal. It contains Gln26-Glu161. |
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| GITR/TNFRSF18 |
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| Human |
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| Q9Y5U5-1 |
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| Gln26-Glu161 |
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| The protein has a predicted MW of 41.3 kDa. Due to glycosylation, the protein migrates to 45-55 kDa based on the Tris-Bis PAGE result. |
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| Immobilized Human GITR Ligand Trimer, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human GITR, hFc Tag with the EC50 of 0.2ug/ml determined by ELISA. See testing image for detail. |
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| C-hFc |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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