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| Human GITR Ligand/TNFSF18 Trimer Protein (LTP10547) |
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| LTP10547 |
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| 100ug |
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$473 In stock |
| Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due to the important role that GITR plays in regulating immune functions, agonistic stimulation of GITR is a promising therapeutic concept. |
| Recombinant Human GITR Ligand/TNFSF18 Trimer Protein is expressed from Expi293 with monomeric hFc tag at the N-terminal. It contains Gln50-Ser177. |
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| GITR Ligand/TNFSF18 Trimer |
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| Human |
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| Q9UNG2 |
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| Gln50-Ser177 |
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| The protein has a predicted MW of 70.2 kDa. Due to glycosylation, the protein migrates to 75-85 kDa based on the Tris-Bis PAGE result. |
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| The affinity constant of 4.47 nM as determined in SPR assay (Biacore T200). See testing image for detail. |
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| N-monomeric hFc |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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