|
| Human GITR/TNFRSF18 Protein (LTP10804) |
|
| LTP10804 |
|
| 100ug |
|
|
$406 In stock |
| GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. |
| Recombinant Human GITR/TNFRSF18 Protein is expressed from Expi293 with His tag at the C-terminal. It contains Gln26-Glu161. |
|
| GITR/TNFRSF18 |
|
| Human |
|
| Q9Y5U5-1 |
|
| Gln26-Glu161 |
|
| The protein has a predicted MW of 15.4 kDa. Due to glycosylation, the protein migrates to 25-28 kDa based on the Tris-Bis PAGE result. |
|
| Immobilized Human GITR, His Tag at 0.5ug (100ul/Well) on the plate. Dose response curve for Anti-GITR Antibody, hFc Tag with the EC50 of 27.9ng/ml determined by ELISA (QC Test). The affinity constant of 4.47 nM as determined in SPR assay (Biacore T200). See testing image for detail. |
|
| C-His |
|
| Expi293 |
|
| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
|
| Less than 1EU per ug by the LAL method. |
|
| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization. |
|
| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
| Shipped at ambient temperature. |
|
| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
|
|  |
