Catalog Number | LT9009 |
| Product Name | Histone H4 (1-25) K5Ac-GSGSK(Biotin) |
| Product Quantity | 1 mg |
| Sequence | SGRG-K(Ac)-GGKGLGKGGAKRHRKVLRDN-GSGSK(Biotin) |
| Molecular Weight | 3274.9 |
| Purity | ≥95% |
| Scientific Background | H4K5ac is an acetylated histone H4 mark associated with newly synthesized histone deposition and transcriptionally active chromatin. This peptide places acetylation specifically at Lys5 within H4(1-25) and adds a distal biotin handle for capture and quantitative binding studies. |
| Research Applications | - H4K5ac reader-protein studies
- histone acetylation assays
- chromatin protein pull-downs
- epigenetic inhibitor research
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| Experimental Notes | Acetylation neutralizes the positive charge of Lys5 and can alter recognition by bromodomains and other chromatin proteins. Compare directly with the otherwise matched unacetylated biotinylated H4(1-25) control. |
| Selected References | - Overlapping but Distinct Patterns of Histone Acetylation by the Human Coactivators p300 and PCAF within Nucleosomal Substrates
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