| Product Name | Histone H4 (1-25) K16Ac-GSGSK(Biotin) |
| Product Quantity | 1 mg |
| Sequence | SGRGKGGKGLGKGGA-K(Ac)-RHRKVLRDN-GSGSK(Biotin) |
| Molecular Weight | 3274.9 |
| Purity | ≥95% |
| Mechanism & Biological Significance | H4K16ac is a prominent acetyl-lysine state that reduces positive charge on the H4 tail and is closely linked to chromatin accessibility, higher-order chromatin organization, and acetyl-lysine reader recognition. The GSGSK(Biotin) extension enables affinity capture without changing the defined K16 acetylation site. |
| Published Research Context | The exact the commercial supplier AS-65209 construct is explicitly listed in the peer-reviewed key-resources table for yeast-surface-display mapping of epigenome enzyme residue specificities. The publication specifies the H4(1-25) K16Ac sequence with the same GSGSK(Biotin) C-terminal handle and identifies the commercial supplier AS-65209-1. |
| Research Applications | - H4K16 acetylation studies
- epigenome-enzyme specificity mapping
- chromatin-reader binding assays
- streptavidin immobilization and pull-down
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| Experimental Considerations | The vendor record reports 1 mg at $453, MW 3274.9, and >95% peptide purity. The source-workbook MW 3317.0 is inconsistent with the monoacetylated construct and is corrected. |
| Selected Scientific References | - Mapping the residue specificities of epigenome enzymes by yeast surface display
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