| Product Name | Histone H4 (1-25) K12Ac-GSGSK(Biotin) |
| Product Quantity | 1 mg |
| Sequence | SGRGKGGKGLG-K(Ac)-GGAKRHRKVLRDN-GSGSK(Biotin) |
| Molecular Weight | 3274.9 |
| Purity | ≥95% |
| Mechanism & Biological Significance | This peptide presents the H4 Lys12 acetylation mark in a 25-residue histone H4 N-terminal context and adds a C-terminal GSGSK(Biotin) affinity handle. H4K12 acetylation is associated with chromatin assembly and transcription-linked histone regulation and can be interrogated using modification-sensitive binding or enzyme assays. |
| Published Research Context | The exact the commercial supplier AS-65208 construct is listed in the key-resources table of a peer-reviewed epigenome-enzyme specificity study. That paper explicitly identifies the sequence SGRGKGGKGLG-K(Ac)-GGAKRHRKVLRDNGSGS-K(Biotin) and the commercial supplier catalog AS-65208-1 among the histone peptide reagents used to map residue specificity of chromatin-modifying enzymes. |
| Research Applications | - histone acetyltransferase/deacetylase specificity studies
- epigenome-enzyme substrate profiling
- streptavidin capture and binding assays
- H4 acetylation-state comparisons
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| Experimental Considerations | The current vendor record gives MW 3274.9 and price $453 for 1 mg. The old source workbook listed MW 3317.0, which corresponds to an additional acetylation and is therefore corrected here rather than propagated. |
| Selected Scientific References | - Mapping the residue specificities of epigenome enzymes by yeast surface display
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