Histone H4 (1-21)-GGK(Biotin)

This H4(1-21) construct is N-terminally acetylated and carries a C-terminal GGK(Biotin) handle. It provides an immobilizable reference H4 tail for histone-binding assays, pull-down experiments and comparison with site-specifically modified H4 peptides.

• histone protein pull-downs
• streptavidin immobilization
• chromatin-reader binding
• epigenetic assay controls

The N-terminal acetyl group and GGK(Biotin) extension are part of the exact chemical identity. It should not be conflated with free H4(1-21) or H4(1-25)-GSGSK(Biotin).

1. Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro