Histone H3 (1-21), Lys9 Dimethylated

H3K9me2 is a repressive histone modification associated with transcriptionally silent chromatin domains. Defined H3K9me2 peptides are useful for studying lysine methyltransferases, demethylases and methyl-lysine reader domains involved in heterochromatin organization.

• H3K9 methyltransferase studies
• histone demethylase assays
• heterochromatin research
• methyl-lysine reader binding

H3K9me2 should be distinguished from H3K9me1 and H3K9me3 because methylation state influences genomic localization and protein recognition.

1. Histone Methyltransferases Direct Different Degrees of Methylation to Define Distinct Chromatin Domains