Catalog Number | LT9012 |
| Product Name | Histone H3 (1-21), Lys4 Dimethylated |
| Product Quantity | 1 mg |
| Sequence | ART-K(Me2)-QTARKSTGGKAPRKQLA |
| Molecular Weight | 2282.8 |
| Formula | C96H176N36O28 |
| Purity | ≥95% |
| Scientific Background | H3K4me2 is a dimethylated form of the histone H3 N-terminal tail. H3K4 methylation is strongly associated with regulatory chromatin, and H3K4me2 is enriched around transcription start sites and at subsets of active regulatory regions. Defined H3K4me2 peptides are useful substrates and standards for lysine demethylase and reader-domain studies. |
| Research Applications | - H3K4 demethylase assays
- chromatin-reader binding
- histone methylation studies
- epigenetic enzyme screening
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| Experimental Notes | Dimethylation at Lys4 is chemically distinct from H3K4me1 and H3K4me3 and can produce different affinities for chromatin reader proteins and modifying enzymes. |
| Selected References | - A unique H3K4me2 profile marks tissue-specific gene regulation
- Global Mapping of H3K4me1 and H3K4me3 Reveals the Chromatin State-Based Cell Type-Specific Gene Regulation in Human Treg Cells
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