Histone H3 (1-21) K9Me2-GGK(Biotin)-NH2

This H3(1-21) construct carries Lys9 dimethylation plus a C-terminal GGK-biotin handle and terminal amide. It provides an immobilizable H3K9me2 ligand for studying methylation-dependent interactions, including chromatin reader proteins and enzymes acting on repressive histone marks.

• H3K9me2 pull-down assays
• chromatin reader binding
• epigenetic protein screening
• streptavidin-based interaction assays

The GGK-biotin linker and C-terminal amide make this a distinct chemical reagent from both free H3K9me2 and free-acid biotinylated H3 peptides.

1. Functional dynamics of H3K9 methylation during meiotic prophase progression