Catalog Number | LT9016 |
| Product Name | Histone H3 (1-21) K4Ac-GGK(Biotin) |
| Product Quantity | 1 mg |
| Sequence | ART-K(Ac)-QTARKSTGGKAPRKQLA-GGK(Biotin) |
| Molecular Weight | 2765.4 |
| Formula | |
| Purity | ≥95% |
| Scientific Background | H3K4ac is an acetylated histone H3 modification that can alter the interaction of the H3 tail with chromatin-associated proteins. Studies in fission yeast have shown that H3K4 acetylation can function as a chromodomain switch by weakening Chp1 association and facilitating HP1-family interactions. |
| Research Applications | - H3K4 acetylation studies
- chromodomain binding assays
- heterochromatin research
- epigenetic reader screening
|
| Experimental Notes | Acetylation neutralizes the Lys4 side-chain charge. This peptide should be compared with otherwise matched unmodified or methylated H3 constructs rather than treated as interchangeable with H3K4 methylation states. |
| Selected References | - A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly
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