| Product Name | Histone H3 (1-10) K4Me3 |
| Product Quantity | 1 mg |
| Sequence | ART-K(Me3)-QTARKS |
| Molecular Weight | 1189.5 |
| Purity | ≥95% |
| Mechanism & Biological Significance | H3K4me3 is a promoter-associated trimethyl-lysine mark recognized by PHD fingers and other chromatin-reader modules. H3(1-10) K4Me3 is a minimal, sequence-defined ligand for studying this recognition chemistry. |
| Published Research Context | The exact H3(1-10)K4me3 peptide has been used directly in crystallographic and binding studies of ING4 and was also obtained from the commercial supplier for biochemical studies of BPTF PHD recognition. These publications establish direct experimental use of the same 10-residue trimethylated construct. |
| Research Applications | - PHD-finger binding assays
- H3K4me3 recognition studies
- protein-peptide structural studies
- chromatin-reader biophysics
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| Experimental Considerations | Binding can depend strongly on peptide length, terminal chemistry and methylation state. Keep H3(1-10) K4Me3 distinct from H3K4me2, H3K4me1 and longer H3K4me3 peptides. |
| Selected Scientific References | - Molecular Basis of Histone H3K4me3 Recognition by ING4
- The conformation of the histone H3 tail inhibits association of the BPTF PHD finger with the nucleosome
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