| Product Name | Beta-Amyloid (1-40), A21G Flemish Mutation |
| Catalog Number | LT9146 |
| Sequence | DAEFRHDSGYEVHHQKLVFFGEDVGSNKGAIIGLMVGGVV |
| Mutation | A21G |
| Molecular Weight | 4316.1 |
| Purity | ≥95% |
| Mechanism & Biological Significance | The Flemish A21G mutation lies in the central Aβ region and is associated with hereditary amyloid disease and cerebral amyloid angiopathy. It changes aggregation and assembly behavior relative to wild-type Aβ. |
| Published Research Context | A21G Aβ40 was directly synthesized by Fmoc chemistry, purified and characterized for comparative ion-mobility/oligomerization studies together with wild-type and other familial Aβ variants. |
| Research Applications | - Flemish mutation studies
- Aβ40 oligomerization and aggregation
- cerebral amyloid angiopathy research
- familial mutant comparisons
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| Experimental Considerations | Mutation identity and the Aβ C-terminal boundary are integral to this reagent. Compare with sequence-matched wild-type peptide using the same pretreatment, buffer, concentration, incubation time, and aggregation protocol. |
| Selected Scientific References | - Familial Alzheimer’s disease mutations differentially alter amyloid β-protein oligomerization
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