Catalog Number | LT8882 |
Product Name | Cys(Npys)-TAT (47-57), FAM-Labeled |
Product Quantity | 1 mg |
Sequence | C(Npys)YGRKKRRQRRR-K(FAM)-NH2 |
Molecular Weight | 2302.6 |
Formula | C99H148N38O23S2 |
Purity | ≥95% |
Scientific Background | C(Npys)YGRKKRRQRRR-K(FAM)-NH2 is a multifunctional Tat(47-57) cell-penetrating peptide containing both an Npys-activated N-terminal cysteine and a FAM-labeled lysine. The construct combines a thiol-reactive conjugation handle with a fluorescent reporter, enabling simultaneous cargo coupling and fluorescence-based tracking of Tat-containing conjugates. |
Research Applications | - fluorescent TAT conjugation studies
- thiol cargo coupling
- cellular uptake and localization
- multifunctional CPP assay development
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Experimental Notes | The activated cysteine and FAM label both alter the chemistry of the parent TAT peptide. Fluorescence measurements should be protected from light, and conjugation kinetics should be validated for the intended thiol-containing cargo. |
Selected References | - Single molecule sensitive multivalent polyethylene glycol probes for RNA imaging
- Cellular Uptake of Antisense Morpholino Oligomers Conjugated to Arginine-Rich Peptides
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